sequential delivery of bmp2

Controlled Sequential Delivery of PDGF-BB and BMP-2

Corpus ID 113794865.Controlled Sequential Delivery of PDGF-BB and BMP-2 for Vascularized Bone Regeneration @inproceedings{Bayer2017ControlledSD,title={Controlled Sequential Delivery of PDGF-BB and BMP-2 for Vascularized Bone Regeneration},author={E.Bayer},year={2017} } Sequential BMP-2/BMP-7 delivery from polyester The sequential delivery of BMP-2 and BMP-7 provided slightly lower proliferation than did simultaneous delivery,but the highest alkaline phosphatase activity of all indicated a synergistic effect on the osteogenic differentiation of mesenchymal stem cells caused by the use of the two growth factors in a sequential fashion.

(PDF) Effect of local sequential VEGF and BMP-2 delivery

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration.Biomaterials,2009.Laura Creemers.Wouter Dhert.Andras Heijink.Avudaiappan Maran.Lichun Lu.Ana Quintela. scaffold BMP2 VEGF/BMP2 scaffold B 70 * 60 * Bone volume (mm3) 50 40 30 20 10 0 Unfilled Empty VEGF BMP-2 VEGF defect scaffold scaffold 1.IntroductionJNM Journal of Nanomaterials 1687-4129 1687-4110 Hindawi 10.1155/2020/4929151 4929151 Research Article Sequential Delivery of BMP2-Derived Peptide P24 by Thiolated Chitosan/Calcium Carbonate Composite Microspheres Scaffolds for Bone Regeneration Wang Zhaozhen 1 Liu Xujie 2 3 Martin Vidmi Taolam 1 Abdi Mohamed Abdullahi 1 Chen Lijun 4 Gong Yong 12345Next

2.9.Real-Time Polymerase Chain Reaction (PCR)Author Emily BayerPublish Year 2017In situ bone regeneration with sequential delivery of

The sequential release of these two bioactive molecules from scaffolds is profitable for the enhancement of bone regeneration,since the initial fast release of aptamer drives BMSCs homing to defect areas at early stages,in addition to a sustained release of BMP2,which maintains an effective dose of BMP-2 to subsequently induce the osteogenic differentiation of BMSCs.Author Tingfang Sun,Chunqing Meng,Qiuyue Ding,Keda Yu,Xianglin Zhang,Wancheng Zhang,Wenqing Tian,Qi Publish Year 2021(PDF) Incorporation of a sequential BMP-2/BMP-7 delivery The sequential delivery of BMP-2 and BMP-7,on the other hand,led to the highest ALP activity per cell (while suppressing proliferation) indicating the synergistic effect of using both growth factors holds promise for the production of tissue engineered bone.

Author Tingfang Sun,Chunqing Meng,Qiuyue Ding,Keda Yu,Xianglin Zhang,Wancheng Zhang,Wenqing Tian,Qi Publish Year 2021Sequential delivery of BMP-2 and BMP-7 for bone

Sequential delivery of BMP-2 and BMP-7 for bone regeneration using a heparinized collagen membrane.by J-Y Jo,S-I Jeong,Y-M Shin,S-S Kang,S-E Kim,C-M Jeong,J-B Huh.International journal of oral and maxillofacial surgery.Read more related scholarly scientific articles and abstracts.Author Tingfang Sun,Chunqing Meng,Qiuyue Ding,Keda Yu,Xianglin Zhang,Wancheng Zhang,Wenqing Tian,Qi Publish Year 2021Sequential dual-drug delivery of BMP-2 and alendronate Jan 12,2021·Our findings suggest that the sequential delivery of BMP-2 and ALN from the scaffolds results in a synergistic effect on bone regeneration,which is unprecedented.Therefore,such aAuthor Zhaozhen Wang,Xujie Liu,Vidmi Taolam Martin,Mohamed Abdullahi Abdi,Lijun Chen,Yong Gong,Yiran Publish Year 2020In situ bone regeneration with sequential delivery of Apr 24,2021·The sequential release of these two bioactive molecules from scaffolds is profitable for the enhancement of bone regeneration,since the initial fast release of aptamer drives BMSCs homing to defect areas at early stages,in addition to a sustained release of BMP2,which maintains an effective dose of BMP-2 to subsequently induce the osteogenic differentiation of BMSCs.

Calvarial Bone Regeneration Is Enhanced by Sequential

At 3 weeks,FGF-2 and BMP-2 delivery increased bone formation more than BMP-2 alone,particularly in the center of the defect,confirming that the proliferation of the Sca-1 positive osteoprogenitors by FGF-2 was associated with increased bone healing.Cited by 14Publish Year 2017Author Bing-jun Zhang,Lei He,Zhi-wei Han,Xin-guo Li,Wei Zhi,Wei Zheng,Yan-dong Mu,Jie WengIs Accessible For Free FalseSequential differentiation of mesenchymal stem cells in an Apr 19,2012·It is feasible that given the appropriate culture conditions,with fine tuning of the sequential delivery of TGF and BMP2 and/or the inclusion of additional growth and differentiation factors (e.g.,IGF,PDGF,FGF) chondrocyte differentiation and maturation could be controlled to achieve a balance between proliferation and hypertrophy which Cited by 169Publish Year 2012Author Sungwoo Kim,Yunqing Kang,Chad A.Krueger,Milan Sen,John B.Holcomb,Di Chen,Joseph C.Wenke,YuEstimated Reading Time 40 secsIn situ bone regeneration with sequential delivery of Apr 24,2021·In situ bone regeneration with sequential delivery of aptamer and BMP2 from an ECM-based scaffold fabricated by cryogenic free-form extrusion Tingfang Sun,a,1 Chunqing Meng,a,1 Qiuyue Ding,a Keda Yu,a Xianglin Zhang,b Wancheng Zhang,b Wenqing Tian,b Qi Zhang,c Xiaodong Guo,a,Bin Wu,b,and Zekang Xiong a,

Cited by 169Publish Year 2012Author Sungwoo Kim,Yunqing Kang,Chad A.Krueger,Milan Sen,John B.Holcomb,Di Chen,Joseph C.Wenke,YuSequential Delivery of BMP2-Derived Peptide P24 by

Therefore,a more reliable carrier for sequential delivery of growth factors to the target has received widespread atten- tion.As a carrier for localization and delivery of BMP-2,thesystemincludes polylactic-glycolic acid,absorbablecolla- gen.Chitosan is also a well-tested vehicle.Cited by 22Publish Year 2017Author Gloria Gronowicz,Emily Jacobs,Tao Peng,Li Zhu,Marja Hurley,Liisa T KuhnCalvarial Bone Regeneration Is Enhanced by Sequential Dec 01,2017·A drug delivery coating for synthetic bone grafts has been developed to provide sequential delivery of multiple osteoinductive factors to better mimic aspects of the natural regenerative process.The coating is composed of a biomimetic calcium phosphate (bCaP) layer that is applied to a synthetic bone graft and then covered with a poly- l Cited by 22Publish Year 2017Author Gloria Gronowicz,Emily Jacobs,Tao Peng,Li Zhu,Marja Hurley,Liisa T KuhnFigure 4 Sequential Delivery of BMP2-Derived Peptide P24 Sequential Delivery of BMP2-Derived Peptide P24 by Thiolated Chitosan/Calcium Carbonate Composite Microspheres Scaffolds for Bone Regeneration.Figure 4.Histology of the cranial specimens at 4 and 8 weeks after implantation in vivo.(a) Hematoxylin and eosin staining of harvested tissues in Control,TCS/CA,TCS-5%P24/CA,and TCS-10%P24/CA

Cited by 28Publish Year 2017Author Farzana Sharmin,Casey McDermott,Jay Lieberman,Archana Sanjay,Yusuf KhanEnhanced osteogenesis of multilayered pore-closed

On the basis of such a construction,sequential delivery of OGP and BMP-2 occurred in a coordinated manner through an orchestrated sequence of spatial changes,targeting different bone healing stages.Cited by 29Publish Year 2015Author J.-Y.Jo,S.-I.Jeong,Y.-M.Shin,S.-S.Kang,S.-E.Kim,C.-M.Jeong,J.-B.Huh(PDF) Sequential Delivery of BMP2-Derived Peptide P24 by Jul 13,2020·Sequential Delivery of BMP2-Derived Peptide P24 by Thiolated Chitosan/Calcium Carbonate Composite Microspheres Scaffolds for Bone Regeneration JulyCited by 3Publish Year 2020Author Erfan Dashtimoghadam,Farahnaz Fahimipour,Farahnaz Fahimipour,Nikita Tongas,Lobat TayebiDual growth factor delivery from biofunctionalized Dual Growth Factor Delivery From Biofunctionalized Allografts Sequential VEGF and BMP-2 Release to Stimulate Allograft Remodeling Farzana Sharmin,1,2 Casey McDermott,2,3 Jay Lieberman,4 Archana Sanjay,5,6 Yusuf Khan1,2,3,5,6 1Department of Materials Science and Engineering,University of Connecticut,Storrs,Connecticut,2Institute for Regenerative Engineering,

Cited by 3Publish Year 2020Author Erfan Dashtimoghadam,Farahnaz Fahimipour,Farahnaz Fahimipour,Nikita Tongas,Lobat TayebiMicrofluidic fabrication of microcarriers with sequential

Jul 16,2020·1.Verrier,S.et al.Tissue engineering and regenerative approaches to improving the healing of large bone defects.Eur.Cell Mater.32,87110 (2016).CAS PubMed Google Scholar 2.Ramasamy,S.K.et al.Blood flow controls bone vascular function and osteogenesis.Nat.Commun.7,13601 (2016).ADS PubMed PubMed Central Google Scholar 3.Ramasamy,[]Cited by 3Publish Year 2020Author Erfan Dashtimoghadam,Farahnaz Fahimipour,Farahnaz Fahimipour,Nikita Tongas,Lobat TayebiSequential BMP-2/BMP-7 delivery from polyester The sequential delivery of BMP-2 and BMP-7 provided slightly lower proliferation than did simultaneous delivery,but the highest alkaline phosphatase activity of all indicated a synergistic effectCited by 4Publish Year 2021Author Dongtak Lee,Maierdanjiang Wufuer,Insu Kim,Tae Hyun Choi,Byung Jun Kim,Hyo Gi Jung,Byoungjun JeIncorporation of a sequential BMP-2/BMP-7 deliveryIncorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering Pinar Yilgora,Kadriye Tuzlakoglub,Rui L.Reisb,Nesrin Hasircia,c,d,Vasif Hasircia,d,e,* aMETU,BIOMAT,Department of Biotechnology,06531 Ankara,Turkey b 3Bs Research Group Biomaterials,Biodegradables and Biomimetics,IBB-Institute for Biotechnology and

Cited by 4Publish Year 2021Author Dongtak Lee,Maierdanjiang Wufuer,Insu Kim,Tae Hyun Choi,Byung Jun Kim,Hyo Gi Jung,Byoungjun JeSequential delivery of BMP-2 and BMP-7 for bone

Jul 01,2015·It was found that the sequential delivery of BMP-2 then BMP-7 facilitated mesenchymal cell proliferation and differentiation into osteoblasts.Based on the results of their study,we expected that the sequential application of BMP-2 and BMP-7 would effectively enhance bone regeneration as compared to BMP-2 alone.Effect of local sequential VEGF and BMP-2 delivery on a sequential fashion are required.Apart from its delivery purpose,such a biomaterial should also act as a biologically and biome-chanically compatible framework that enhances angiogenesis,osteogenesis,and mechanical stability.A previously designed sustained delivery vehicle capable of supporting BMP-2-induced bone formation was modied Estimated Reading Time 12 minsMicrofluidic fabrication of microcarriers with sequential Jul 01,2020·In order to harness the regenerative potential of growth factors and stimulate bone healing,present study aims to design multifunctional cell therapy microcarriers with the capability of sequential delivery of essential growth factors,bone morphogenetic protein 2 (BMP-2) and vascular endothelial growth factor (VEGF).

Estimated Reading Time 5 minsControlled Sequential Delivery of PDGF-BB and BMP-2 for

Bayer,Emily (2017) Controlled Sequential Delivery of PDGF-BB and BMP-2 for Vascularized Bone Regeneration.Doctoral Dissertation,University of Pittsburgh.Microfluidic fabrication of microcarriers with sequential The presented approach to design bioactive microcarriers offer sustained sequential delivery of bone ECM chemical cues and offer an ideal stabilized 3D microenvironment for patient-specific cell Microfluidic fabrication of microcarriers with sequential Wound instability and poor functional vascularization in bone tissue engineering lead to lack of tissue integration and ultimate failure of engineered grafts.In order to harness the regenerative potential of growth factors and stimulate bone healing,present study aims to design multifunctional cell therapy microcarriers with the capability of sequential delivery of essential growth factors,bone morphogenetic

Sequential Delivery of BMP-2 and IGF-1 Using a Chitosan

The purpose of this study was to develop and characterize a chitosan gelgelatin microsphere MSs dual delivery system for sequential release of bone morphogenetic protein 2 BMP 2 and insulin like growth factor 1 IGF 1 to enhance osteoblast differentiation in vitro.We made and characterized the delivery system based on its degree of cross linking,degradation,and release kinetics.Sequential delivery of BMP-2 and IGF-1 using a chitosan The purpose of this study was to create and characterize a sequential delivery system consisting of a chitosan gel and gelatin microspheres (MSs) to achieve a sequential release of BMP-2 and IGF-1.We hypothesized that an initial release of BMP-2 from the chitosan gel followed by the release of IGF-1 from the gelatin MSs would enhance osteoblastic activity of bone cells.Sequential dual-drug delivery of BMP-2 and alendronate Our findings suggest that the sequential delivery of BMP-2 and ALN from the scaffolds results in a synergistic effect on bone regeneration,which is unprecedented.Therefore,such a system exhibits potential for the application of cell-free tissue engineering.

The Use of Sequential VEGF- and BMP2-Releasing

Jun 17,2021·The Use of Sequential VEGF- and BMP2-Releasing Biodegradable Scaffolds in Rabbit Mandibular Defects Nilüfer Çakr-Özkan DDS ,Sinan Eri DDS ,Esengül Bekar DDS ,B.Zuhal Altunkaynak DDS,MD ,Yonca Betil Kabak DVM and Elfide Gizem Kvrak Journal of Oral and Maxillofacial Surgery,2017-01-01,Volume 75,Issue 1,[]mRNA Forward (5 - 3) Reverse (5 - 3) COL1a1 GCAACAGTCGCTTCACCTACA CAATGTCCAAGGGAGCCACAT GAPDH TGTGTCCGTCGTGGATCTGA TTGCTGTTGAAGTCGCAGGAG ALP GGCTGGAGATGGACAAATTCC CCGAGTGGTAGTCACAATGCC Runx2 CCAACCCACGAATGCACTATC TAGTGAGTGGTGGCGGACATAC Jun 28 2021Publish Year:2020Sequential Delivery of BMP2-Derived Peptide P24 by Was this helpful?Sequential Delivery of BMP2-Derived Peptide P24 by The combination of tissue-engineered bone scaffolds with osteogenic induction molecules is an important strategy for critical-sized bone defects repair.We synthesized a novel thiolated chitosan/calcium carbonate composite microsphere (TCS-P24/CA) scaffold as a carrier for bone morphogenetic protein 2- (BMP2-) derived peptide P24 and evaluated the release kinetics of P24.The effect of TCS-PIntroductionMaterials and MethodsResultsDiscussionConclusionsAcknowledgmentsRegeneration of critical-sized bone defects resulting from tumor resection and congenital malformation or trauma is still a challenging problem in orthopedic surgery [1 1.L.Li,G.Zhou,Y.Wang,G.Yang,S.Ding,and S.Zhou,Controlled dual delivery of BMP-2 and dexamethasone by nanoparticle-embedded electrospun nanofibers for the efficient repair of critical-sized rat calvarial defect, Biomaterials,vol.37,pp.218229,2015.View at Publisher SiteGoogle Scholar See in References 3 1.Y.Chen,X.Liu,RSee more on hindawiAuthor Zhaozhen Wang,Xujie Liu,Vidmi Taolam Martin,Mohamed Abdullahi Abdi,Lijun Chen,Yong Gong,Yiran Publish Year 2020Sequential delivery of BMP-2 and IGF-1 using a chitosan This combinational delivery system provided an initial release of BMP-2 followed by a slow and sustained release of IGF-1.Significantly greater alkaline phosphatase activity was found in W-20-17 cells treated with the sequential delivery system compared with other treatments (P<0.05) after a

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